Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Flavonoids from Licorice Roots and 4-Arylcoumarins

Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Flavonoids from Licorice Roots and 4-Arylcoumarins

Isoliquiritigenin, glabridin, licoarylcoumarin and licoricidin were identified as strong inhibitors of adenosine 3', 5'-cyclic monophosphate (cAMP) phosphodiesterase in waste materials which were obtained during the industrial extraction of glycyrrhizin from licorice roots. The structure-a...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1991/04/25, Vol.39(4), pp.930-933
Hauptverfasser: KUSANO, Ayumu, NIKAIDO, Tamotsu, KUGE, Takashi, OHMOTO, Taichi, MONACHE, G.Delle, BOTTA, Bruno, BOTTA, Maurizio, SAITOH, Tamotsu
Format: Artikel
Sprache:eng
Schlagworte:
3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors
3-arylcoumarin
4-arylcoumarin
Animals
Biological and medical sciences
cAMP phosphodiesterase
Cattle
Coumarins - pharmacology
flavonoid
Flavonoids - pharmacology
General pharmacology
Glycyrrhiza
inhibitor
licorice root
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal
Structure-Activity Relationship
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Zusammenfassung:Isoliquiritigenin, glabridin, licoarylcoumarin and licoricidin were identified as strong inhibitors of adenosine 3', 5'-cyclic monophosphate (cAMP) phosphodiesterase in waste materials which were obtained during the industrial extraction of glycyrrhizin from licorice roots. The structure-activity relationships of 12 flavonoids from licorice roots and 34 4-arylcoumarins were studied. In 4-arylcoumarins, 5, 7-dihydroxy derivatives were generally highly inhibitory towards cAMP phosphodiesterase.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.39.930