A Cytotoxic Substance from Sangre de Grado

Taspine has been isolated as a cytotoxic substance from Sangre de Grado, sap of Croton palanostigma (Euphorbiaceae), by bioassay guided fractionation. The cytotoxicity (IC50) of taspine was found to be 0.39 μg/ml against KB cells and 0.17 μg/ml against V-79 cells.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1991/04/25, Vol.39(4), pp.1041-1042
Hauptverfasser:	ITOKAWA, Hideji, ICHIHARA, Yoshitatsu, MOCHIZUKI, Miwako, ENOMORI, Tamami, MORITA, Hiroshi, SHIROTA, Osamu, INAMATSU, Mutsumi, TAKEYA, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	alkaloid Alkaloids - isolation & purification Alkaloids - pharmacology Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Croton palanostigma cytotoxicity Euphorbiaceae General pharmacology KB cell Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - analysis Sangre de Grado taspine Tumor Cells, Cultured - drug effects V-79 cell
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Beschreibung
Zusammenfassung:	Taspine has been isolated as a cytotoxic substance from Sangre de Grado, sap of Croton palanostigma (Euphorbiaceae), by bioassay guided fractionation. The cytotoxicity (IC50) of taspine was found to be 0.39 μg/ml against KB cells and 0.17 μg/ml against V-79 cells.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.39.1041