CD8+ T cells from HIV-1-infected individuals inhibit acute infection by human and primate immunodeficiency viruses

T lymphocytes expressing the CD8 surface antigen block HIV replication in CD4+ peripheral blood cells from HIV-infected individuals. We report here that CD4+ cells from HIV seronegative donors, when infected in vitro with HIV, also do not replicate virus when cocultured with CD8+ T cells from HIV-in...

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Veröffentlicht in:Cellular immunology 1991-10, Vol.137 (2), p.420-428
Hauptverfasser: Walker, Christopher M., Thomson-Honnebier, Graeme A., Hsueh, Frank C., Erickson, Ann L., Pan, Li-Zhen, Levy, Jay A.
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Sprache:eng
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Zusammenfassung:T lymphocytes expressing the CD8 surface antigen block HIV replication in CD4+ peripheral blood cells from HIV-infected individuals. We report here that CD4+ cells from HIV seronegative donors, when infected in vitro with HIV, also do not replicate virus when cocultured with CD8+ T cells from HIV-infected individuals. CD8+ cells from HIV-uninfected donors did not show this effect on virus replication. HLA-restriction of the antiviral response was not observed, and virus-containing cells were not eliminated from culture. The antiviral activity was broadly cross-reactive, as CD8+ cells from individuals infected only with HIV-1 suppressed the replication of diverse strains of HIV-1 and HIV-2, as well as the simian immunodeficiency virus. This ability of CD8+ cells to control HIV replication could play an important role in the maintenance of an asymptomatic state in HIV-infected individuals.
ISSN:0008-8749
1090-2163
DOI:10.1016/0008-8749(91)90090-X