In vitro activity of sparfloxacin (AT-4140 and CI-978), a new quinolone antimicrobial agent, against Haemophilus and Gram-positive cocci

In vitro activity of sparfloxacin (AT-4140 and CI-978), a new quinolone antimicrobial agent, against Haemophilus and Gram-positive cocci

Sparfloxacin (AT-4140 and CI-978) was evaluated for activity against 194 clinical isolates of staphylococci, streptococci, Enterococcus faecalis, anaerobic Gram-positive cocci, and Haemophilus sp. The MIC of sparfloxacin for >93% of the strains tested was ⩽0.5 μg/ml. Sparfloxacin demonstrated inc...

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Veröffentlicht in:Diagnostic microbiology and infectious disease 1991-07, Vol.14 (4), p.355-360
Hauptverfasser: Rudrik, James T., Ferrigno, Susanne R., Gee, Sharon L.
Format: Artikel
Sprache:eng
Schlagworte:
4-Quinolones
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - pharmacology
Fluoroquinolones
Gram-Positive Bacteria - drug effects
Haemophilus - drug effects
Humans
Microbial Sensitivity Tests
Staphylococcus - drug effects
Streptococcus - drug effects
Vancomycin - pharmacology
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Zusammenfassung:Sparfloxacin (AT-4140 and CI-978) was evaluated for activity against 194 clinical isolates of staphylococci, streptococci, Enterococcus faecalis, anaerobic Gram-positive cocci, and Haemophilus sp. The MIC of sparfloxacin for >93% of the strains tested was ⩽0.5 μg/ml. Sparfloxacin demonstrated increased activity against enterococci, staphylococci, pneumococci, and anaerobic cocci when compared with ciprofloxacin.
ISSN:0732-8893
1879-0070
DOI:10.1016/0732-8893(91)90028-E