Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)

We have established PCR assays for the genes coding for the major proteins of the desmosome type of cell junction, the desmosomal cadherins DGI (desmoglein) and DGII/III (desmocollins), and the plaque proteins DPI/II (desmoplakin) and DPIII (plakoglobin) and used them to test human-mouse and human-r...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 1991-07, Vol.10 (3), p.640-645
Hauptverfasser:	ARNEMANN, J, SPURR, N. K, WHEELER, G. N, PARKER, A. E, BUXTON, R. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences chromosome 18 chromosome 6 chromosome 7 chromosome 9 Chromosome Mapping Chromosomes, Human, Pair 18 Chromosomes, Human, Pair 6 Chromosomes, Human, Pair 7 Chromosomes, Human, Pair 9 Classical genetics, quantitative genetics, hybrids Cytoskeletal Proteins - genetics desmocollin Desmocollins Desmogleins desmoplakin Desmoplakins Desmosomes Fundamental and applied biological sciences. Psychology gamma Catenin Genes Genetics of eukaryotes. Biological and molecular evolution Human Humans Hybrid Cells Mice Molecular Sequence Data plakoglobin Polymerase Chain Reaction Rats
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Zusammenfassung:	We have established PCR assays for the genes coding for the major proteins of the desmosome type of cell junction, the desmosomal cadherins DGI (desmoglein) and DGII/III (desmocollins), and the plaque proteins DPI/II (desmoplakin) and DPIII (plakoglobin) and used them to test human-mouse and human-rat somatic cell hybrids with different contents of human chromosomes. From these data we were able to assign DGI to chromosome 18 (DSG), DGII/III to chromosome 9p (DSC), DPI/II to chromosome 6p21-ter(DSP), and DPIII to chromosome 7 (JUP).
ISSN:	0888-7543 1089-8646
DOI:	10.1016/0888-7543(91)90446-L