Hyperhomocysteinemia as risk factor for ischemic and hemorrhagic stroke in newborn infants

We studied the association between plasma total homocysteine concentrations and the occurrence of stroke in newborn infants (n = 24). Newborn infants with stroke had significantly higher mean total homocysteine concentrations compared with 94 healthy newborn infants (9.3 vs 7.4 μmol/L). The odds rat...

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Veröffentlicht in:	The Journal of pediatrics 2002-09, Vol.141 (3), p.429-431
Hauptverfasser:	Hogeveen, Marije, Blom, Henk J., van Amerongen, Marjolein, Boogmans, Bas, van Beynum, Ingrid M., van de Bor, Margot
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Brain Ischemia - epidemiology Brain Ischemia - etiology Cerebral Hemorrhage - epidemiology Cerebral Hemorrhage - etiology Emergency and intensive care: neonates and children. Prematurity. Sudden death Humans Hyperhomocysteinemia - complications Infant, Newborn Intensive care medicine Logistic Models Medical sciences Netherlands - epidemiology Retrospective Studies Risk Factors Stroke - epidemiology Stroke - etiology
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Zusammenfassung:	We studied the association between plasma total homocysteine concentrations and the occurrence of stroke in newborn infants (n = 24). Newborn infants with stroke had significantly higher mean total homocysteine concentrations compared with 94 healthy newborn infants (9.3 vs 7.4 μmol/L). The odds ratio for neonatal stroke was 3.95 (95” CI 1.53-10.16) at the 80” cutoff level. (J Pediatr 2002;141:429-31)
ISSN:	0022-3476 1097-6833
DOI:	10.1067/mpd.2002.126598