Effects of the angiotensin converting enzyme inhibitor, benazepril, on the sino-aortic baroreceptor heart rate reflex

The effects of monotherapy with the angiotensin converting enzyme inhibitor benazepril (10 mg once daily) on cardiovascular baroreceptor reflexes were determined in 10 patients with essential hypertension using a randomized, double-blind, placebo-controlled, cross-over protocol. Early sino-aortic ba...

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Veröffentlicht in:Cardiovascular drugs and therapy 1991-09, Vol.5 (4), p.747-751
Hauptverfasser: WEST, J. N. W, CHAMPION DE CRESPIGNY, P. C, STALLARD, T. J, LITTLER, W. A
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Sprache:eng
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Zusammenfassung:The effects of monotherapy with the angiotensin converting enzyme inhibitor benazepril (10 mg once daily) on cardiovascular baroreceptor reflexes were determined in 10 patients with essential hypertension using a randomized, double-blind, placebo-controlled, cross-over protocol. Early sino-aortic baroreceptor/heart rate reflex resetting was apparent with acute treatment; this effect persisted throughout the active treatment period. Changes in baroreflex sensitivity did not appear to mediate the hypotensive effect of benazepril.
ISSN:0920-3206
1573-7241
DOI:10.1007/BF03029750