Initial report of bladder carcinoma following combined bladder‐drained pancreas and kidney transplantation

Highshaw RA, Tunuguntla HSGR, Perez RV, Gandour‐Edwards R, Evans CP. Initial report of bladder carcinoma following combined bladder‐drained pancreas and kidney transplantation. Clin Transplant 2002: 16: 383–386. © Blackwell Munksgaard, 2002 Although long‐term survival of a functional allograft requiring long‐term immunosuppressive therapy is responsible for higher incidence of non‐urothelial cancers in renal allograft recipients than in normal population, the incidence of bladder cancer is uncommon and carcinoma of the bladder in the setting of combined kidney–pancreas transplantation has not been reported to date. We herein report a case of poorly differentiated invasive adeno‐squamous cell carcinoma of the bladder following renal and bladder‐drained pancreatic transplantation in a 44‐yr‐old lady with long‐standing insulin dependent diabetes mellitus, which necessitated radical extirpation. Management implications are reviewed.