Choroid plexus cysts in the mid-trimester fetus-practical application suggests superiority of an individualized risk method of counseling for trisomy 18

An erratum has been published for this article in Prenatal Diagnosis 23 (3) 2003, 268. Objectives Analysis of a referral population of patients with choroid plexus cysts (CPCs) was performed to compare an average risk method of counseling to an individualized risk method. Methods A total of 395 patients referred to a Prenatal Diagnosis Center were included, of whom 341 had isolated CPCs and 54 had associated ultrasound abnormalities. For isolated CPCs, an average risk of 1/150 for aneuploidy was compared to an individualized risk assessment [prior risk as determined by maternal age or serum screening multiplied by the likelihood ratio established by Gupta et al. (1997)]. Accuracy, cost, and procedure‐related losses were assessed. Results Both methods resulted in 100% sensitivity. The individualized method resulted in greater specificity, decreased costs, and (theoretically) fewer procedure‐related pregnancy losses. Conclusions An individualized risk method of counseling utilizing the likelihood ratios established by Gupta et al. (1997) was superior to an average risk method for assessing trisomy 18 risk in the setting of CPC detected in mid‐trimester. Copyright © 2002 John Wiley & Sons, Ltd.