Apparent elastic modulus and hysteresis of skeletal muscle cells throughout differentiation

Departments of 1 Biomedical Engineering and 2 Medicine, Duke University, Durham, North Carolina 27708 The effect of differentiation on the transverse mechanical properties of mammalian myocytes was determined by using atomic force microscopy. The apparent elastic modulus increased from 11.5 ± 1.3 ...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2002-10, Vol.283 (4), p.C1219-C1227
Hauptverfasser:	Collinsworth, Amy M, Zhang, Sarah, Kraus, William E, Truskey, George A
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinin - metabolism Animals Antineoplastic Agents, Phytogenic - pharmacology Cell Differentiation - physiology Cell Line Colchicine - pharmacology Cytochalasin D - pharmacology Diacetyl - analogs & derivatives Diacetyl - pharmacology Elasticity - drug effects Enzyme Inhibitors - pharmacology Life Sciences (General) Mice Mice, Inbred C3H Microscopy, Atomic Force Microscopy, Confocal Microtubules - drug effects Muscle Contraction - physiology Muscle, Skeletal - cytology Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Myosins - metabolism Paclitaxel - pharmacology Space life sciences Stress, Mechanical Tubulin - metabolism
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Zusammenfassung:	Departments of 1 Biomedical Engineering and 2 Medicine, Duke University, Durham, North Carolina 27708 The effect of differentiation on the transverse mechanical properties of mammalian myocytes was determined by using atomic force microscopy. The apparent elastic modulus increased from 11.5 ± 1.3 kPa for undifferentiated myoblasts to 45.3 ± 4.0 kPa after 8 days of differentiation ( P
ISSN:	0363-6143 1522-1563
DOI:	10.1152/ajpcell.00502.2001