Cytokeratin expression in adenocarcinomas of the esophagogastric junction: A comparative study of adenocarcinomas of the distal esophagus and of the proximal stomach

Adenocarcinomas of the esophagogastric junction form a heterogeneous group of tumors. We aimed to evaluate the value of the expression pattern of cytokeratins 7, 19, and 20 for their diagnosis and classification. A total of 85 cases of adenocarcinoma of the distal esophagus and 67 cases of adenocarc...

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Veröffentlicht in:	The American journal of surgical pathology 2002-09, Vol.26 (9), p.1213-1221
Hauptverfasser:	TANIERE, Philippe, BORGHI-SCOAZEC, Giovanna, SAURIN, Jean-Christophe, LOMBARD-BOHAS, Catherine, BOULEZ, Jean, BERGER, Francoise, HAINAUT, Pierre, SCOAZEC, Jean-Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma - surgery Adult Aged Aged, 80 and over Barrett Esophagus - pathology Biological and medical sciences Biomarkers, Tumor - analysis Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal Neoplasms - surgery Esophagogastric Junction - metabolism Esophagogastric Junction - pathology Esophagogastric Junction - surgery Esophagus Female Gastroenterology. Liver. Pancreas. Abdomen Humans Keratins - metabolism Male Medical sciences Middle Aged Neoplasm Proteins - analysis Predictive Value of Tests Sensitivity and Specificity Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach Neoplasms - surgery Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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Zusammenfassung:	Adenocarcinomas of the esophagogastric junction form a heterogeneous group of tumors. We aimed to evaluate the value of the expression pattern of cytokeratins 7, 19, and 20 for their diagnosis and classification. A total of 85 cases of adenocarcinoma of the distal esophagus and 67 cases of adenocarcinoma of the proximal stomach, defined on strict topographical criteria, were investigated. About 90% of the adenocarcinomas of distal esophagus were positive for cytokeratins 7 and 19, in contrast to
ISSN:	0147-5185 1532-0979
DOI:	10.1097/00000478-200209000-00012