Superantigen Enhancement of Specific Immunity: Antibody Production and Signaling Pathways

Superantigens are microbial proteins that induce massive activation, proliferation, and cytokine production by CD4+ T cells via specific Vbeta elements on the TCR. In this study we examine superantigen enhancement of Ag-specific CD4+ T cell activity for humoral B cell responses to T-dependent Ags BS...

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Veröffentlicht in:	The Journal of immunology (1950) 2002-09, Vol.169 (6), p.2907-2914
Hauptverfasser:	Torres, Barbara A, Perrin, George Q, Mujtaba, Mustafa G, Subramaniam, Prem S, Anderson, Amy K, Johnson, Howard M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - pharmacology Animals Antibody Specificity - immunology CD4-Positive T-Lymphocytes - enzymology CD4-Positive T-Lymphocytes - immunology Cells, Cultured Enterotoxins - administration & dosage Enterotoxins - immunology Enterotoxins - pharmacology Epitopes, T-Lymphocyte - immunology Female HIV Antibodies - biosynthesis HIV Antibodies - blood HIV Envelope Protein gp120 - administration & dosage HIV Envelope Protein gp120 - immunology Humans Immunity, Cellular - immunology Immunoglobulin G - biosynthesis Immunoglobulin G - blood Injections, Intraperitoneal Lymphocyte Activation - immunology MAP Kinase Signaling System - immunology Mice Mice, Inbred C57BL Serum Albumin, Bovine - administration & dosage Serum Albumin, Bovine - immunology Serum Albumin, Bovine - pharmacology Superantigens - administration & dosage Superantigens - immunology
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