Adiponectin is not altered with exercise training despite enhanced insulin action

Departments of 1 Physiology, 2 Exercise and Sport Science Human Performance Laboratory, and 3 Surgery, East Carolina University, Greenville 27858; 4 Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710; and 5 Linco Research Inc., St. Charles, Missouri 63304 Adiponectin is an adipocytokine that is hypothesized to be involved in the regulation of insulin action. The purpose of the present investigation was to determine whether plasma adiponectin is altered in conjunction with enhanced insulin action with exercise training. An insulin sensitivity index (S I ) and fasting levels of glucose, insulin, and adiponectin were assessed before and after 6 mo of exercise training (4 days/wk for ~45 min at 65-80% peak O 2 consumption) with no loss of body mass (PRE, 91.9 ± 3.8 kg vs. POST, 91.6 ± 3.9 kg) or fat mass (PRE, 26.5 ± 1.8 kg vs. POST, 26.7 ± 2.2 kg). Insulin action significantly ( P