Apelin, the Novel Endogenous Ligand of the Orphan Receptor APJ, Regulates Cardiac Contractility

ABSTRACT—The orphan receptor APJ and its recently identified endogenous ligand, apelin, exhibit high levels of mRNA expression in the heart. However, the functional importance of apelin in the cardiovascular system is not known. In isolated perfused rat hearts, infusion of apelin (0.01 to 10 nmol/L)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Circulation research 2002-09, Vol.91 (5), p.434-440
Hauptverfasser:	Szokodi, István, Tavi, Pasi, Földes, Gábor, Voutilainen-Myllylä, Sari, Ilves, Mika, Tokola, Heikki, Pikkarainen, Sampsa, Piuhola, Jarkko, Rysä, Jaana, Tóth, Miklós, Ruskoaho, Heikki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenomedullin Animals Animals, Genetically Modified Apelin Apelin Receptors Biological and medical sciences Calcium Channels - physiology Carrier Proteins - genetics Carrier Proteins - metabolism Carrier Proteins - pharmacology Dose-Response Relationship, Drug Endothelin-1 - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation Heart Heart Ventricles - cytology Heart Ventricles - drug effects In Vitro Techniques Intercellular Signaling Peptides and Proteins Isoproterenol - pharmacology Ligands Male Membrane Potentials - drug effects Myocardial Contraction - drug effects Peptides - pharmacology Potassium Channels - physiology Rats Rats, Inbred SHR Rats, Inbred WKY Rats, Sprague-Dawley Receptors, Dopamine D2 - genetics Receptors, Dopamine D2 - metabolism Receptors, G-Protein-Coupled RNA, Messenger - genetics RNA, Messenger - metabolism Sodium-Calcium Exchanger - metabolism Sodium-Hydrogen Exchangers - metabolism Stress, Mechanical Time Factors Ventricular Function Vertebrates: cardiovascular system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	ABSTRACT—The orphan receptor APJ and its recently identified endogenous ligand, apelin, exhibit high levels of mRNA expression in the heart. However, the functional importance of apelin in the cardiovascular system is not known. In isolated perfused rat hearts, infusion of apelin (0.01 to 10 nmol/L) induced a dose-dependent positive inotropic effect (EC5033.1±1.5 pmol/L). Moreover, preload-induced increase in dP/dtmax was significantly augmented (P
ISSN:	0009-7330 1524-4571
DOI:	10.1161/01.RES.0000033522.37861.69