Temperature regulation of the cryptococcal phenoloxidase

Melanin formation at 37 degrees C has been proposed as a virulence factor in Cryptococcus neoformans. However, whereas catecholamine uptake is maintained at this temperature, phenoloxidase, which catalyses the oxidation of catecholamine to melanin, is severely decreased in most wild type strains cul...

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Veröffentlicht in:	Journal of medical and veterinary mycology 1991, Vol.29 (2), p.121-124
Hauptverfasser:	JACOBSON, E. S, EMERY, H. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Catecholamines - metabolism Cryptococcus neoformans - enzymology Cryptococcus neoformans - pathogenicity Fundamental and applied biological sciences. Psychology Melanins - biosynthesis Microbiology Monophenol Monooxygenase - metabolism Mycology Oxidation-Reduction Temperature Urease - metabolism Virulence
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Zusammenfassung:	Melanin formation at 37 degrees C has been proposed as a virulence factor in Cryptococcus neoformans. However, whereas catecholamine uptake is maintained at this temperature, phenoloxidase, which catalyses the oxidation of catecholamine to melanin, is severely decreased in most wild type strains cultivated at 37 degrees C.
ISSN:	0268-1218