Seven-transmembrane receptors

Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most versatile family of membrane receptors, are also the most common target of therapeutic drugs. Recent findings indicate that the classical models of G-protein coupling and activation of second-messenger-generating e...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2002-09, Vol.3 (9), p.639-650
Hauptverfasser:	Lefkowitz, Robert J, Pierce, Kristen L, Premont, Richard T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic receptors Animals Cell Membrane - metabolism Dimerization Down-Regulation Heterotrimeric GTP-Binding Proteins - metabolism Hormones Humans Kinases Peptides Proteins Receptors, Cell Surface - chemistry Receptors, Cell Surface - classification Receptors, Cell Surface - metabolism Retina Signal Transduction Yeasts
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Beschreibung
Zusammenfassung:	Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most versatile family of membrane receptors, are also the most common target of therapeutic drugs. Recent findings indicate that the classical models of G-protein coupling and activation of second-messenger-generating enzymes do not fully explain their remarkably diverse biological actions.
ISSN:	1471-0072 1471-0080
DOI:	10.1038/nrm908