Salivary duct carcinoma: cytokeratin 14 as a marker of in-situ intraductal growth

Aims: The aim of this study was to determine the immunoprofile of salivary duct carcinoma and to differentiate intraductal growth from invasive growth. Methods and results: We applied a panel of antibodies (cytokeratins 7, 8, 13, 14, 19, vimentin and α‐smooth muscle actin) in five cases of salivar...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Histopathology 2002-09, Vol.41 (3), p.244-249
Hauptverfasser:	De Araújo, V C, Loducca, S V L, Sobral, A P V, Kowalski, L P, Soares, F, De Araújo, N S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Aged Biological and medical sciences Biomarkers, Tumor - metabolism cytokeratins Female Humans Immunohistochemistry Keratins - metabolism Male Medical sciences Middle Aged Otorhinolaryngology. Stomatology Parotid Neoplasms - metabolism Parotid Neoplasms - pathology salivary duct carcinoma Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Aims: The aim of this study was to determine the immunoprofile of salivary duct carcinoma and to differentiate intraductal growth from invasive growth. Methods and results: We applied a panel of antibodies (cytokeratins 7, 8, 13, 14, 19, vimentin and α‐smooth muscle actin) in five cases of salivary duct carcinoma. This panel is currently used for identification of different components of salivary gland tumours in our laboratory. All tumour cells were positive for cytokeratins 7 and 8. Few neoplastic structures expressed cytokeratin 14 in cells surrounding tumour islands. Conclusion: The finding of cytokeratin 14 was important to confirm the in‐situ intraductal growth, which probably characterizes this low‐grade neoplasm.
ISSN:	0309-0167 1365-2559
DOI:	10.1046/j.1365-2559.2002.01454.x