Cyclic AMP-mediated modulation of epileptiform afterdischarge generation in rat hippocampal slices

This study assessed the effects of drugs which manipulate the cAMP system on afterdischarges (ADs) induced in the CA1 region of rat hippocampal slices. The adenylate cyclase activator forskolin (50 μM) and the phosphodiesterase inhibitor rolipram (0.1 and 1 μM) enhanced AD generation. These effects...

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Veröffentlicht in:	Brain research 2002-09, Vol.949 (1), p.157-161
Hauptverfasser:	Higashima, Masato, Ohno, Koji, Koshino, Yoshifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Adenylyl Cyclases - metabolism Afterdischarge Animals Biological and medical sciences cAMP cAMP-dependent kinase Colforsin - pharmacology Cyclic AMP - analogs & derivatives Cyclic AMP - metabolism Cyclic AMP - pharmacology Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Electrophysiology Enzyme Activators - pharmacology Enzyme Inhibitors - pharmacology Epilepsy Epilepsy - metabolism Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampal slice Hippocampus - drug effects Hippocampus - metabolism Isoquinolines - pharmacology Male Medical sciences Nervous system (semeiology, syndromes) Neurology Phosphodiesterase Inhibitors - pharmacology Rats Rats, Sprague-Dawley Rolipram - pharmacology Seizures - metabolism Sulfonamides Thionucleotides - pharmacology
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Zusammenfassung:	This study assessed the effects of drugs which manipulate the cAMP system on afterdischarges (ADs) induced in the CA1 region of rat hippocampal slices. The adenylate cyclase activator forskolin (50 μM) and the phosphodiesterase inhibitor rolipram (0.1 and 1 μM) enhanced AD generation. These effects were reversed by the cAMP-dependent protein kinase inhibitors H-89 (5 μM) and Rp-cAMPS (100 μM). These findings suggest that AD generation can be modulated through cAMP generation and the subsequent activation of the cAMP-dependent protein kinase.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(02)02976-1