Chronic estrogen deficiency leads to molecular aberrations related to neurodegenerative changes in follitropin receptor knockout female mice

The follitropin receptor knockout (FORKO) mouse undergoes ovarian failure, thereby providing an animal model to investigate the consequences of the depletion of circulating estrogen in females. The estrogen deficiency causes marked defects in the female reproductive system, obesity, and skeletal abn...

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Veröffentlicht in:	Neuroscience 2002-01, Vol.114 (2), p.493-506
Hauptverfasser:	Tam, J, Danilovich, N, Nilsson, K, Sairam, M.R, Maysinger, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Animals Biological and medical sciences Cell Differentiation - drug effects Cell Differentiation - genetics Cells, Cultured Central Nervous System - metabolism Central Nervous System - pathology Central Nervous System - physiopathology choline acetyltransferase Choline O-Acetyltransferase - metabolism CNS dorsal root ganglia Enzyme Inhibitors - pharmacology estrogen Estrogens - deficiency Estrogens - metabolism Estrogens - pharmacology Female follicle stimulating hormone Fundamental and applied biological sciences. Psychology Ganglia, Spinal - cytology Ganglia, Spinal - drug effects Ganglia, Spinal - growth & development General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions Mice Mice, Knockout mitogen-activated protein kinase Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Neurites - drug effects Neurites - ultrastructure Neurodegenerative Diseases - etiology Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - physiopathology neurofilament Neurofilament Proteins - metabolism Peripheral Nervous System - metabolism Peripheral Nervous System - pathology Peripheral Nervous System - physiopathology Receptors, FSH - deficiency Receptors, FSH - genetics Testosterone - metabolism Up-Regulation - genetics Vertebrates: endocrinology
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Zusammenfassung:	The follitropin receptor knockout (FORKO) mouse undergoes ovarian failure, thereby providing an animal model to investigate the consequences of the depletion of circulating estrogen in females. The estrogen deficiency causes marked defects in the female reproductive system, obesity, and skeletal abnormalities. In light of estrogen’s known pleiotropic effects in the nervous system, our study examined the effects of genetically induced estrogen–testosterone imbalance on this system in female FORKO mice. Circulating concentrations of 17-β-estradiol (E2) in FORKO mice are significantly decreased (FORKO −/−: 1.13±0.34 pg/ml; wild-type +/+: 17.6±3.5 pg/ml, P
ISSN:	0306-4522 1873-7544
DOI:	10.1016/S0306-4522(02)00278-6