Stability of diltiazem in different biological fluids

The hydrolysis of diltiazem in biological fluids: whole blood, plasma, and gastric fluid was investigated under conditions considered close to the physiological situation. The most significant rate of hydrolytic degradation was found in whole blood (half‐life of 27h), followed by plasma (half‐life o...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 1991-07, Vol.12 (5), p.327-334
Hauptverfasser:	McLean, Angus M., Cefali, Eugenio A., Roden, Jennifer S., Gonzalez, Mario A., Bialer, Meir
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotransformation Body Fluids - chemistry Cardiovascular system Chromatography, High Pressure Liquid Diltiazem Diltiazem - analysis Diltiazem - pharmacokinetics Diltiazem - pharmacology Drug Stability Humans In Vitro Techniques Medical sciences Miscellaneous Pharmacology. Drug treatments Stability
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Zusammenfassung:	The hydrolysis of diltiazem in biological fluids: whole blood, plasma, and gastric fluid was investigated under conditions considered close to the physiological situation. The most significant rate of hydrolytic degradation was found in whole blood (half‐life of 27h), followed by plasma (half‐life of 88h), while the least significant degradation rate was observed in gastric fluid (half‐life 153h). The kinetic profiles of diltiazem hydrolysis indicate that hydrolytic degradation in the biological fluids makes a minimal contribution to the clearance and disposition of the drug.
ISSN:	0142-2782 1099-081X
DOI:	10.1002/bdd.2510120502