Novel Glycodendrimers Self-Assemble to Nanoparticles which Function as Polyvalent Ligands In Vitro and In Vivo

Size is important: Noncovalent nanoparticles are formed by the self‐assembly of glycodendrimers containing both a ligand and a self‐assembling moiety. Particle size reaches an optimum at the second and third generation, larger dendritic species show less efficient self‐assembly. It is the nanoparticles, not the individual molecules, that governs their potency as polyvalent receptor blockers (see scheme), both in vitro and in vivo.