Aminocyclopentadienyl Ruthenium Chloride: Catalytic Racemization and Dynamic Kinetic Resolution of Alcohols at Ambient Temperature

Aminocyclopentadienyl Ruthenium Chloride: Catalytic Racemization and Dynamic Kinetic Resolution of Alcohols at Ambient Temperature

Ruthenium–enzyme tandem catalysis: The novel racemization catalyst 1 improves the dynamic kinetic resolution (DKR) of secondary alcohols dramatically. The DKR proceeds at room temperature with isopropenyl acetate as an acyl donor. In addition, the DKR is faster even with much less lipase than in pre...

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Veröffentlicht in:Angewandte Chemie International Edition 2002-07, Vol.41 (13), p.2373-2376
Hauptverfasser: Choi, Jun Ho, Kim, Yu Hwan, Nam, Se Hyun, Shin, Seung Tae, Kim, Mahn-Joo, Park, Jaiwook
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric synthesis
homogeneous catalysis
kinetic resolution
lipases
ruthenium
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Zusammenfassung:Ruthenium–enzyme tandem catalysis: The novel racemization catalyst 1 improves the dynamic kinetic resolution (DKR) of secondary alcohols dramatically. The DKR proceeds at room temperature with isopropenyl acetate as an acyl donor. In addition, the DKR is faster even with much less lipase than in previous DKRs.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20020703)41:13<2373::AID-ANIE2373>3.0.CO;2-7