[Ir4(CO)12]-Catalyzed Coupling Reaction of Imidazoles with Aldehydes in the Presence of a Hydrosilane to Give 2-Substituted Imidazoles

[Ir4(CO)12]-Catalyzed Coupling Reaction of Imidazoles with Aldehydes in the Presence of a Hydrosilane to Give 2-Substituted Imidazoles

A significant increase in yield is observed when DMAD is added to the reaction of 1‐methylimidazole (1) with aldehydes 2 and diethylmethylsilane in the presence of a catalytic amount of [Ir4(CO)12] to produce 2‐(1‐diethylmethylsiloxyalkyl)imidazoles 3. DMAD=dimethyl acetylenedicarboxylate.

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Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2002-08, Vol.41 (15), p.2779-2781
Hauptverfasser: Fukumoto, Yoshiya, Sawada, Katsutoshi, Hagihara, Motoyuki, Chatani, Naoto, Murai, Shinji
Format: Artikel
Sprache:eng
Schlagworte:
aldehydes
Aldehydes - chemistry
alkylation
Biological Factors - chemistry
Catalysis
imidazoles
Imidazoles - chemical synthesis
Imidazoles - chemistry
iridium
Iridium - chemistry
silanes
Silanes - chemistry
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Beschreibung
Zusammenfassung:A significant increase in yield is observed when DMAD is added to the reaction of 1‐methylimidazole (1) with aldehydes 2 and diethylmethylsilane in the presence of a catalytic amount of [Ir4(CO)12] to produce 2‐(1‐diethylmethylsiloxyalkyl)imidazoles 3. DMAD=dimethyl acetylenedicarboxylate.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20020802)41:15<2779::AID-ANIE2779>3.0.CO;2-J