Pd-Catalyzed Alkyl to Aryl Migration and Cyclization: An Efficient Synthesis of Fused Polycycles via Multiple C−H Activation

A novel palladium migration methodology for the synthesis of complex fused polycycles has been developed. This process involves 1,4-palladium alkyl to aryl migrations via through-space C−H activation, followed by intramolecular arylation or an intermolecular Heck reaction providing a very efficient...

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Veröffentlicht in:	Journal of the American Chemical Society 2004-06, Vol.126 (24), p.7460-7461
Hauptverfasser:	Huang, Qinhua, Fazio, Alessia, Dai, Guangxiu, Campo, Marino A, Larock, Richard C
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Chemistry Cyclization Exact sciences and technology Heterocyclic Compounds, 4 or More Rings - chemical synthesis Heterocyclic Compounds, 4 or More Rings - chemistry Molecular Structure Organic chemistry Palladium - chemistry Polycyclic Compounds - chemical synthesis Polycyclic Compounds - chemistry
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container_end_page	7461
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container_title	Journal of the American Chemical Society
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creator	Huang, Qinhua Fazio, Alessia Dai, Guangxiu Campo, Marino A Larock, Richard C
description	A novel palladium migration methodology for the synthesis of complex fused polycycles has been developed. This process involves 1,4-palladium alkyl to aryl migrations via through-space C−H activation, followed by intramolecular arylation or an intermolecular Heck reaction providing a very efficient way to synthesize fused ring systems.
doi_str_mv	10.1021/ja047980y
format	Article
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subjects	Catalysis Chemistry Cyclization Exact sciences and technology Heterocyclic Compounds, 4 or More Rings - chemical synthesis Heterocyclic Compounds, 4 or More Rings - chemistry Molecular Structure Organic chemistry Palladium - chemistry Polycyclic Compounds - chemical synthesis Polycyclic Compounds - chemistry
title	Pd-Catalyzed Alkyl to Aryl Migration and Cyclization: An Efficient Synthesis of Fused Polycycles via Multiple C−H Activation
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