Pd-Catalyzed Alkyl to Aryl Migration and Cyclization:  An Efficient Synthesis of Fused Polycycles via Multiple C−H Activation

A novel palladium migration methodology for the synthesis of complex fused polycycles has been developed. This process involves 1,4-palladium alkyl to aryl migrations via through-space C−H activation, followed by intramolecular arylation or an intermolecular Heck reaction providing a very efficient way to synthesize fused ring systems.