New Steroidal Alkaloids from Fritillaria imperialis and Their Cholinesterase Inhibiting Activities

Two new cevanine steroidal alkaloids, impericine (1) and forticine (2) along with known bases delavine (3), persicanidine A (4), and imperialine (5) were isolated from the bulbs of Fritillaria imperialis. The structures of impericine (1) [(20R,22S,25S)-5α-cevanin-23-ene-3β,6β,16β-triol] and forticin...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2002, Vol.50(8), pp.1013-1016
Hauptverfasser:	Atta-ur-Rahman, Akhtar, Muhammad Nadeem, Choudhary, Muhammad Iqbal, Tsuda, Yoshisuke, Sener, Bilge, Khalid, Assad, Parvez, Masood
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholinesterase Alkaloids - chemistry Alkaloids - isolation & purification Biological and medical sciences butyrylcholinesterase cevanine-type Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - isolation & purification forticine Fritillaria - chemistry Fritillaria imperialis General pharmacology impericine Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - isolation & purification Steroids - chemistry Steroids - isolation & purification
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Zusammenfassung:	Two new cevanine steroidal alkaloids, impericine (1) and forticine (2) along with known bases delavine (3), persicanidine A (4), and imperialine (5) were isolated from the bulbs of Fritillaria imperialis. The structures of impericine (1) [(20R,22S,25S)-5α-cevanin-23-ene-3β,6β,16β-triol] and forticine (2) [(20S,22S,25S)-5α-cevanine-3β,6β-diol] were determined with the help of spectroscopic studies. These steroidal bases showed anti-acetylcholinesterase and anti-butyrylcholinesterase inhibitory activity.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.50.1013