A novel melatonin derivative modulates sleep–wake cycle in rats

The aim of this study was to evaluate, in comparison with melatonin (MLT), the effects of a novel 2-melatonin derivative, having a 2-trifluoromethyl group (MLTD) on the sleep–wake cycle in freely behaving rats. Doses of MLTD (100, 300 and 500 nmol/100 μl saline) or MLT (500 nmol/100 μl saline) repla...

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Veröffentlicht in:	Neuroscience letters 2004-07, Vol.364 (3), p.199-202
Hauptverfasser:	Akanmu, Moses A, Songkram, Chalermkiat, Kagechika, Hiroyuki, Honda, Kazuki
Format:	Artikel
Sprache:	eng
Schlagworte:	2-trifluoromethylmelatonin Animals Biological and medical sciences Dose-Response Relationship, Drug Electroencephalography Fundamental and applied biological sciences. Psychology Injections, Intraventricular Male Melatonin Melatonin - administration & dosage Melatonin - chemistry NREM sleep Rats REM sleep Sleep - drug effects Sleep. Vigilance Vertebrates: nervous system and sense organs Wakefulness - drug effects
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Beschreibung
Zusammenfassung:	The aim of this study was to evaluate, in comparison with melatonin (MLT), the effects of a novel 2-melatonin derivative, having a 2-trifluoromethyl group (MLTD) on the sleep–wake cycle in freely behaving rats. Doses of MLTD (100, 300 and 500 nmol/100 μl saline) or MLT (500 nmol/100 μl saline) replaced the i.c.v. infusion of saline during the diurnal infusion period (7:00–17:00). Diurnal infusion of MLTD significantly ( P
ISSN:	0304-3940 1872-7972
DOI:	10.1016/j.neulet.2004.04.047