Impaired nitric oxide synthase pathway in diabetes mellitus: Role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase

An endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA), is elevated in patients with type 2 diabetes mellitus (DM). This study explored the mechanisms by which ADMA becomes elevated in DM. Male Sprague-Dawley rats were fed normal chow or high-fat diet (n=5 in each) with...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2002-08, Vol.106 (8), p.987-992
Hauptverfasser:	LIN, Ken Y, ITO, Akira, ASAGAMI, Tomoko, TSAO, Philip S, ADIMOOLAM, Shanthi, KIMOTO, Masumi, TSUJI, Hideaki, REAVEN, Gerald M, COOKE, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - physiology Animals Antioxidants - pharmacology Aorta - enzymology Arginine - analogs & derivatives Arginine - blood Arginine - metabolism Arginine - physiology Associated diseases and complications Biological and medical sciences Cell Line Cells, Cultured Cyclic GMP - biosynthesis Diabetes Mellitus, Experimental - enzymology Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Enzyme Inhibitors - blood Glucose - pharmacology Humans Male Medical sciences Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - enzymology Nitric Oxide Synthase - antagonists & inhibitors Oxidative Stress Polyethylene Glycols - pharmacology Rats Rats, Sprague-Dawley Superoxide Dismutase - pharmacology
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Zusammenfassung:	An endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA), is elevated in patients with type 2 diabetes mellitus (DM). This study explored the mechanisms by which ADMA becomes elevated in DM. Male Sprague-Dawley rats were fed normal chow or high-fat diet (n=5 in each) with moderate streptozotocin injection to induce type 2 DM. Plasma ADMA was elevated in diabetic rats (1.33+/-0.31 versus 0.48+/-0.08 micromol/L; P
ISSN:	0009-7322 1524-4539
DOI:	10.1161/01.CIR.0000027109.14149.67