Synthesis and application in asymmetric C-C bond formation of solution phase ligand libraries of monodentate phosphoramidites

Synthesis and application in asymmetric C-C bond formation of solution phase ligand libraries of monodentate phosphoramidites

A library of 96 unique monodentate phosphoramidite ligands has been synthesized in solution and used in the asymmetric conjugate addition of potassium vinyltrifluoroborate to enones resulting in up to 88% ee.

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Veröffentlicht in:Organic & biomolecular chemistry 2004-06, Vol.2 (12), p.1682-1684
Hauptverfasser: Duursma, Ate, Lefort, Laurent, Boogers, Jeroen A F, de Vries, André H M, de Vries, Johannes G, Minnaard, Adriaan J, Feringa, Ben L
Format: Artikel
Sprache:eng
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Zusammenfassung:A library of 96 unique monodentate phosphoramidite ligands has been synthesized in solution and used in the asymmetric conjugate addition of potassium vinyltrifluoroborate to enones resulting in up to 88% ee.
ISSN:1477-0520
1477-0539
DOI:10.1039/b404996a