Tipping the scales of selection with BAFF

Two recent Immunity papers link peripheral tolerance with the ability of developing B cells to capture BAFF. These findings suggest that an increase in effective BAFF levels leads to autoreactive B cell maturation.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2004-06, Vol.20 (6), p.655-656
1. Verfasser:	Cancro, Michael P
Format:	Artikel
Sprache:	eng
Schlagworte:	B-Cell Activating Factor B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - metabolism Bone marrow Cell Differentiation Competition Immune Tolerance Ligands Membrane Proteins - metabolism Studies Tumor Necrosis Factor-alpha - metabolism
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Beschreibung
Zusammenfassung:	Two recent Immunity papers link peripheral tolerance with the ability of developing B cells to capture BAFF. These findings suggest that an increase in effective BAFF levels leads to autoreactive B cell maturation.
ISSN:	1074-7613 1097-4180
DOI:	10.1016/j.immuni.2004.06.001