Phenotypic polymorphism of CYP2A6 activity in a Chinese population

To investigate the distribution characteristics of CYP2A6 activity in a Chinese population and to examine the sex-related differences in CYP2A6 activities. One hundred and twenty healthy volunteers, 63 men and 57 women, were included in the study. Cytochrome P450 (CYP) 2A6 activity was measured usin...

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Veröffentlicht in:	European journal of clinical pharmacology 2002-08, Vol.58 (5), p.333-337
Hauptverfasser:	PING XU, HUANG, Song-Lin, ZHU, Rong-Hua, HAN, Xing-Mei, ZHOU, Hong-Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aryl Hydrocarbon Hydroxylases - genetics Aryl Hydrocarbon Hydroxylases - metabolism Biological and medical sciences China Chromatography, High Pressure Liquid Coumarins - pharmacokinetics Cytochrome P-450 CYP2A6 Female General pharmacology Humans Male Medical sciences Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Phenotype Polymorphism, Genetic Umbelliferones - urine
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Zusammenfassung:	To investigate the distribution characteristics of CYP2A6 activity in a Chinese population and to examine the sex-related differences in CYP2A6 activities. One hundred and twenty healthy volunteers, 63 men and 57 women, were included in the study. Cytochrome P450 (CYP) 2A6 activity was measured using the ratio of urinary 7-hydroxycoumarin (7-OHC) excreted in 8 h after a coumarin dose. The concentrations of 7-OHC in urine were determined using high performance liquid chromatography. A 300-fold interindividual variation of CYP2A6 activity was shown in the studied Chinese population. The coefficient of variation of CYP2A6 activity was 27.2%. A Kolmogorov-Smirnov test indicated a non-normal distribution of CYP2A6 activity ( P
ISSN:	0031-6970 1432-1041
DOI:	10.1007/s00228-002-0480-3