Anti-inflammatory and related pharmacological activities of the n-BuOH subfraction of mushroom Phellinus linteus

This study aimed to elucidate the anti-inflammatory and related activities of mushroom Phellinus linteus. The results show that the EtOH extract of Phellinus linteus (PLE) dose-dependently inhibited the mouse ear edema induced by croton oil. Among PLE subfractions, the n-BuOH subfraction showed high...

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Veröffentlicht in:Journal of ethnopharmacology 2004-07, Vol.93 (1), p.141-146
Hauptverfasser: Kim, Sun-Hyoung, Song, Yun-Seon, Kim, Seung-Kook, Kim, Byung-Chul, Lim, Chang-Jin, Park, Eun-Hee
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Sprache:eng
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Zusammenfassung:This study aimed to elucidate the anti-inflammatory and related activities of mushroom Phellinus linteus. The results show that the EtOH extract of Phellinus linteus (PLE) dose-dependently inhibited the mouse ear edema induced by croton oil. Among PLE subfractions, the n-BuOH subfraction showed highest anti-inflammatory activity in croton oil-induced ear edema test. The n-BuOH subfraction also showed highest inhibitory activity on the chick embryo chorioallantoic membrane (CAM) angiogenesis in a dose-dependent manner. PLE could significantly reduce the number of writhing induced by acetic acid in mice, indicating that PLE possesses potent antinociceptive effect mediated by its anti-inflammatory activity. Mycelial extract of six different Phellinus strains were found to contain anti-angiogenic activity in the CAM assay. These results suggest that Phellinus linteus has anti-inflammatory and antinociceptive activities, in addition to its anti-angiogenic activity.
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2004.03.048