Autoantibody in a patient with chronic hepatitis C virus infection showing complete remission after interferon therapy

A 42‐year‐old woman was admitted to Kinashi Ohbayashi Hospital for liver dysfunction. She presented with hepatitis C viral infection accompanied by autoimmune hepatitis‐like serological manifestations, such as antinuclear antibody (ANA), antismooth muscle cell antibody and especially anti‐ribonucleo...

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Veröffentlicht in:	Journal of gastroenterology and hepatology 2002-08, Vol.17 (8), p.925-928
Hauptverfasser:	AKASHI, YOSHIHIRO, INOH, MASAYUKI, SETO, KUNIO, GAMO, NAOYUKI, KUBOKI, MAKOTO, KURATA, NORIYUKI
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiviral Agents - therapeutic use anti‐RNP antibody anti‐SSB antibody Autoantibodies - blood Biological and medical sciences Female hepatitis C Hepatitis C, Chronic - blood Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - pathology Human viral diseases Humans Infectious diseases Interferon-alpha - therapeutic use lupus‐like syndrome Medical sciences Remission Induction Viral diseases Viral hepatitis
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Zusammenfassung:	A 42‐year‐old woman was admitted to Kinashi Ohbayashi Hospital for liver dysfunction. She presented with hepatitis C viral infection accompanied by autoimmune hepatitis‐like serological manifestations, such as antinuclear antibody (ANA), antismooth muscle cell antibody and especially anti‐ribonucleoprotein (RNP) antibody and anti‐SSB antibody. After interferon therapy, hepatitis C virus was not detected and ANA, anti‐RNP antibody and anti‐SSB antibody disappeared. To our knowledge, this is the first reported hepatitis C patient showing anti‐RNP antibody and anti‐SSB antibody, having complete remission after interferon therapy.
ISSN:	0815-9319 1440-1746
DOI:	10.1046/j.1440-1746.2002.02651.x