Combinatorial approaches to synthetic receptors

Combinatorial approaches to synthetic receptors

Combinatorial chemistry can be efficiently used for the synthesis and evaluation of binding properties of libraries of synthetic receptors. This approach has been applied particularly to ‘tweezer’ and other ‘multi-armed’ receptors, and has been used for the identification of receptors for peptides i...

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Veröffentlicht in:Current opinion in chemical biology 2004-06, Vol.8 (3), p.305-310
Hauptverfasser: Srinivasan, Natarajan, Kilburn, Jeremy D
Format: Artikel
Sprache:eng
Schlagworte:
Binding Sites
Biosensing Techniques
Chemistry, Pharmaceutical
Combinatorial Chemistry Techniques
Drug Design
Molecular Structure
Peptide Library
Peptides - chemistry
Peptides - metabolism
Receptors, Drug - analysis
Receptors, Drug - chemistry
Receptors, Drug - metabolism
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Zusammenfassung:Combinatorial chemistry can be efficiently used for the synthesis and evaluation of binding properties of libraries of synthetic receptors. This approach has been applied particularly to ‘tweezer’ and other ‘multi-armed’ receptors, and has been used for the identification of receptors for peptides in aqueous media, and for the development of new sensors and sensor arrays.
ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2004.04.014