Synthesis of taurospongin A: a potent inhibitor of DNA polymerase and HIV reverse transcriptase, using pi-allyltricarbonyliron lactone complexes

The synthesis of taurospongin A has been achieved using, as a key step, a pi-allyltricarbonyliron lactone complex to control a highly stereoselective addition of a methyl group to a carbonyl unit located in the side chain of the complex.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2002-08 (15), p.1624-1625
Hauptverfasser: Hollowood, Christopher J, Ley, Steven V, Yamanoi, Shigeo
Format: Artikel
Sprache:eng
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Zusammenfassung:The synthesis of taurospongin A has been achieved using, as a key step, a pi-allyltricarbonyliron lactone complex to control a highly stereoselective addition of a methyl group to a carbonyl unit located in the side chain of the complex.
ISSN:1359-7345
1364-548X
DOI:10.1039/b204994p