Menstrual cycle dependent changes in blue-on-yellow visual field analysis of young diabetic women with severe non-proliferative diabetic retinopathy

Purpose: To evaluate menstrual cycle dependent changes on blue‐on‐yellow visual fields of diabetic women, and to compare the results with those of healthy women. Methods: Left eyes of 93 normally menstruating women were included in the study, comprising 45 with type‐1 diabetes mellitus and severe non‐proliferative diabetic retinopathy and 48 healthy controls. All subjects underwent baseline complete ocular examination and achromatic visual field analysis. Blue‐on‐yellow visual field tests (short‐wavelength automated perimetry) were performed in both follicular (days 7−10 of the cycle) and luteal phases (days 3−6 before the bleeding) of two consecutive menstrual cycles. Visual field analyses were performed using Humphrey Field Analyser II with full threshold, central 30−2 program. Visual fields were divided into four regions: superior temporal, inferior temporal, superior nasal and inferior nasal. Visual field mean sensitivity (MS) was calculated for all regions separately. Results: The mean ages of diabetic and control subjects were not significantly different (P > 0.05). Mean MS values of the diabetic group were significantly lower than that of the control group (P 0.05). However, diabetic women demonstrated a significant decrease in MS values in the luteal phase (P