Metastasis to bone: causes, consequences and therapeutic opportunities

The most common human cancers --lung, breast and prostate -- have a great avidity for bone, leading to painful and untreatable consequences. What makes some cancers, but not others, metastasize to bone, and how do they alter its physiology? Some of the molecular mechanisms that are responsible have...

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Veröffentlicht in:	Nature reviews. Cancer 2002-08, Vol.2 (8), p.584-593
1. Verfasser:	Mundy, Gregory R
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Neoplasms - drug therapy Bone Neoplasms - metabolism Bone Neoplasms - secondary Breast Neoplasms - pathology Calcium - metabolism Carrier Proteins - metabolism Diphosphonates - metabolism Diphosphonates - therapeutic use Female Glycoproteins - metabolism Glycoproteins - therapeutic use Humans Lung Neoplasms - pathology Male Membrane Glycoproteins - metabolism Osteoprotegerin Prostatic Neoplasms - pathology RANK Ligand Receptor Activator of Nuclear Factor-kappa B Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Cytoplasmic and Nuclear - therapeutic use Receptors, Tumor Necrosis Factor Vitamin D - metabolism Vitamin D - therapeutic use
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Beschreibung
Zusammenfassung:	The most common human cancers --lung, breast and prostate -- have a great avidity for bone, leading to painful and untreatable consequences. What makes some cancers, but not others, metastasize to bone, and how do they alter its physiology? Some of the molecular mechanisms that are responsible have recently been identified, and provide new molecular targets for drug development.
ISSN:	1474-175X 1474-1768
DOI:	10.1038/nrc867