1-(Bicyclopiperazinyl)ethylindoles and 1-(homopiperazinyl)ethyl-indoles as highly selective and potent 5-HT(7) receptor ligands

A novel series of 1-(bicyclopiperazinyl)ethylindole and 1-(homopiperazinyl)ethyl-indole derivatives was synthesized and found to be potent and selective 5-HT(7) receptor ligands.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2002-09, Vol.12 (17), p.2451-2454
Hauptverfasser:	Isaac, Methvin B, Xin, Tao, O'Brien, Anne, St-Martin, David, Naismith, Angela, MacLean, Neil, Wilson, Julie, Demchyshyn, Lidia, Tehim, Ashok, Slassi, Abdelmalik
Format:	Artikel
Sprache:	eng
Schlagworte:	Humans Indoles - chemical synthesis Indoles - pharmacology Ligands Protein Binding Receptors, Serotonin - drug effects Serotonin Antagonists - chemical synthesis Serotonin Antagonists - pharmacology Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	A novel series of 1-(bicyclopiperazinyl)ethylindole and 1-(homopiperazinyl)ethyl-indole derivatives was synthesized and found to be potent and selective 5-HT(7) receptor ligands.
ISSN:	0960-894X