Enantioselective Total Synthesis of (+)-Testudinariol A Using a New Nickel-Catalyzed Allenyl Aldehyde Cyclization
An enantioselective total synthesis of (+)-testudinariol A was completed. A new nickel-catalyzed allenyl aldehyde cyclization was developed in the approach. In addition, an asymmetric anti aldol reaction and a two-directional oxocarbenium ion/vinyl silane condensation were employed as key steps.
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| Veröffentlicht in: | Journal of the American Chemical Society 2002-08, Vol.124 (32), p.9366-9367 |
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| container_end_page | 9367 |
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| container_issue | 32 |
| container_start_page | 9366 |
| container_title | Journal of the American Chemical Society |
| container_volume | 124 |
| creator | Amarasinghe, Kande K. D Montgomery, John |
| description | An enantioselective total synthesis of (+)-testudinariol A was completed. A new nickel-catalyzed allenyl aldehyde cyclization was developed in the approach. In addition, an asymmetric anti aldol reaction and a two-directional oxocarbenium ion/vinyl silane condensation were employed as key steps. |
| doi_str_mv | 10.1021/ja027148y |
| format | Article |
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| ispartof | Journal of the American Chemical Society, 2002-08, Vol.124 (32), p.9366-9367 |
| issn | 0002-7863 1520-5126 |
| language | eng |
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| source | ACS Publications; MEDLINE |
| subjects | Aldehydes - chemistry Alicyclic compounds, terpenoids, prostaglandins, steroids Catalysis Chemistry Exact sciences and technology Nickel - chemistry Organic chemistry Preparations and properties Stereoisomerism Terpenoids Triterpenes - chemical synthesis |
| title | Enantioselective Total Synthesis of (+)-Testudinariol A Using a New Nickel-Catalyzed Allenyl Aldehyde Cyclization |
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