Enantioselective Total Synthesis of (+)-Testudinariol A Using a New Nickel-Catalyzed Allenyl Aldehyde Cyclization

Enantioselective Total Synthesis of (+)-Testudinariol A Using a New Nickel-Catalyzed Allenyl Aldehyde Cyclization

An enantioselective total synthesis of (+)-testudinariol A was completed. A new nickel-catalyzed allenyl aldehyde cyclization was developed in the approach. In addition, an asymmetric anti aldol reaction and a two-directional oxocarbenium ion/vinyl silane condensation were employed as key steps.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of the American Chemical Society 2002-08, Vol.124 (32), p.9366-9367
Hauptverfasser: Amarasinghe, Kande K. D, Montgomery, John
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes - chemistry
Alicyclic compounds, terpenoids, prostaglandins, steroids
Catalysis
Chemistry
Exact sciences and technology
Nickel - chemistry
Organic chemistry
Preparations and properties
Stereoisomerism
Terpenoids
Triterpenes - chemical synthesis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An enantioselective total synthesis of (+)-testudinariol A was completed. A new nickel-catalyzed allenyl aldehyde cyclization was developed in the approach. In addition, an asymmetric anti aldol reaction and a two-directional oxocarbenium ion/vinyl silane condensation were employed as key steps.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja027148y