A General Method for the Formation of Aryl−Sulfur Bonds Using Copper(I) Catalysts

A General Method for the Formation of Aryl−Sulfur Bonds Using Copper(I) Catalysts

We report a mild, palladium-free synthetic protocol for the cross-coupling reaction of aryl iodides and thiols using 10 mol % CuI and 10 mol % neocuproine, with NaOt-Bu as the base, in toluene at 110 °C. Using this protocol, we have shown that a variety of aryl sulfides can be synthesized in excelle...

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Veröffentlicht in:Organic letters 2002-08, Vol.4 (16), p.2803-2806
Hauptverfasser: Bates, Craig G, Gujadhur, Rattan K, Venkataraman, D
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Copper - chemistry
Sulfur - chemistry
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Zusammenfassung:We report a mild, palladium-free synthetic protocol for the cross-coupling reaction of aryl iodides and thiols using 10 mol % CuI and 10 mol % neocuproine, with NaOt-Bu as the base, in toluene at 110 °C. Using this protocol, we have shown that a variety of aryl sulfides can be synthesized in excellent yields from readily available iodides and thiols.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0264105