Calorimetric studies of the action of chitosan- N-2-hydroxypropyl trimethyl ammonium chloride on the growth of microorganisms

The water-soluble quaternary ammonium salt of chitosan was synthesized by reaction of chitosan with glycidyl trimethylammonium chloride. It was characterized by Fourier transform infrared and carbon-13 magnetic resonance spectra. Its microbiostatic effects against Staphylococcus aureus, Escherichia...

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Veröffentlicht in:	International journal of biological macromolecules 2004-04, Vol.34 (1), p.121-126
Hauptverfasser:	Qin, Caiqin, Xiao, Qi, Li, Huirong, Fang, Mu, Liu, Yi, Chen, Xinyou, Li, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antimicrobial activity Biochemistry - methods Calorimetry - methods Candida albicans - drug effects Cell Proliferation - drug effects Chitosan Chitosan - analogs & derivatives Chitosan - chemistry Chitosan - pharmacology Escherichia coli - drug effects Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Microcalorimetry Microorganism Quaternary ammonium salt Solubility Spectroscopy, Fourier Transform Infrared Staphylococcus aureus - drug effects Water
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Beschreibung
Zusammenfassung:	The water-soluble quaternary ammonium salt of chitosan was synthesized by reaction of chitosan with glycidyl trimethylammonium chloride. It was characterized by Fourier transform infrared and carbon-13 magnetic resonance spectra. Its microbiostatic effects against Staphylococcus aureus, Escherichia coli and Candid albicans were explored by microcalorimetry. The antimicrobial activity of the quaternized chitosan was stronger in alkaline condition than that in weak acidic condition.
ISSN:	0141-8130 1879-0003
DOI:	10.1016/j.ijbiomac.2004.03.009