REF-ereeing the Cytoplasmic Fate of mRNA via Nuclear Export

The C. elegans sex-determining gene tra-2 is subject to multiple forms of regulation. A report in the June 4 issue of Molecular Cell now shows that proteins associated with the tra-2 mRNA determine its pathway of nuclear export and influence its cytoplasmic fate. These findings demonstrate an additi...

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Veröffentlicht in:	Developmental Cell 2004-06, Vol.6 (6), p.740-742
Hauptverfasser:	McKee, Adrienne E, Silver, Pamela A
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - genetics Animals Basic Helix-Loop-Helix Transcription Factors Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Cytoplasm - genetics Cytoplasm - metabolism Gene Expression Regulation, Developmental - genetics Membrane Proteins - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Sex Determination Processes Sex Differentiation - genetics
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Beschreibung
Zusammenfassung:	The C. elegans sex-determining gene tra-2 is subject to multiple forms of regulation. A report in the June 4 issue of Molecular Cell now shows that proteins associated with the tra-2 mRNA determine its pathway of nuclear export and influence its cytoplasmic fate. These findings demonstrate an additional level of control and link nuclear export to the regulation of sexual development.
ISSN:	1534-5807 1878-1551
DOI:	10.1016/j.devcel.2004.05.014