Synthesis of ODNs Containing 4-Methylamino-1,8-naphthalimide as a fluorescence probe in DNA

Graphic Synthesis and fluorescence properties of oligodeoxynucleotides containing 4-methylamino-1,8-naphthalimide (NI) have been described. NI was successfully incorporated into DNA without significant destabilization of DNA whilst retaining its high fluorescence quantum yield. The attachment site o...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2002-09, Vol.12 (17), p.2363-2366
Hauptverfasser: Kawai, Kiyohiko, Kawabata, Kazuhiro, Tojo, Sachiko, Majima, Tetsuro
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Sprache:eng
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Zusammenfassung:Graphic Synthesis and fluorescence properties of oligodeoxynucleotides containing 4-methylamino-1,8-naphthalimide (NI) have been described. NI was successfully incorporated into DNA without significant destabilization of DNA whilst retaining its high fluorescence quantum yield. The attachment site of the NI greatly affected its property as an energy acceptor in FRET analysis.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(02)00404-3