A Blue-to-Red Energy-Transfer Thymidine Analogue That Functions in DNA

A Blue-to-Red Energy-Transfer Thymidine Analogue That Functions in DNA

The thymidine analogue 1 is a blue-to-red energy transfer cassette designed to absorb UV light in the 300 nm region and emit it as fluorescence at around 520 nm. When incorporated into DNA, the fluorescence intensity of this modified nucleobase is not significantly reduced by the surrounding structu...

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Veröffentlicht in:Organic letters 2004-05, Vol.6 (11), p.1701-1704
Hauptverfasser: Jiao, Guan-Sheng, Kim, Taeg Gyum, Topp, Michael R, Burgess, Kevin
Format: Artikel
Sprache:eng
Schlagworte:
Base Sequence
DNA - chemistry
DNA - genetics
Energy Transfer
Molecular Structure
Oligodeoxyribonucleotides - chemistry
Oligodeoxyribonucleotides - genetics
Spectrometry, Fluorescence
Thymidine - analogs & derivatives
Thymidine - chemistry
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Beschreibung
Zusammenfassung:The thymidine analogue 1 is a blue-to-red energy transfer cassette designed to absorb UV light in the 300 nm region and emit it as fluorescence at around 520 nm. When incorporated into DNA, the fluorescence intensity of this modified nucleobase is not significantly reduced by the surrounding structure in the oligonucleotides.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol049684w