The Glycosyltransferase UrdGT2 Catalyzes Both C- and O-Glycosidic Sugar Transfers

The Glycosyltransferase UrdGT2 Catalyzes Both C- and O-Glycosidic Sugar Transfers

Sweet success: A natural product glycosyltransferase, UrdGT2 from Streptomyces fradiae Tü2717, is the first glycosyltransferase able to catalyze both C‐glycosidic and O‐glycosidic sugar transfers. These results shed new light on the mechanisms of C‐glycosylation of aromatic compounds, which is signi...

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Veröffentlicht in:Angewandte Chemie International Edition 2004-05, Vol.43 (22), p.2962-2965
Hauptverfasser: Dürr, Clemens, Hoffmeister, Dirk, Wohlert, Sven-Eric, Ichinose, Koji, Weber, Monika, von Mulert, Ursula, Thorson, Jon S., Bechthold, Andreas
Format: Artikel
Sprache:eng
Schlagworte:
Anthraquinones - chemistry
Catalysis
drug design
Glycosylation
glycosyltransferases
Glycosyltransferases - chemistry
Molecular Structure
natural products
Streptomyces - enzymology
streptomycetes
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Zusammenfassung:Sweet success: A natural product glycosyltransferase, UrdGT2 from Streptomyces fradiae Tü2717, is the first glycosyltransferase able to catalyze both C‐glycosidic and O‐glycosidic sugar transfers. These results shed new light on the mechanisms of C‐glycosylation of aromatic compounds, which is significant for chemoenzymatic drug lead derivatization as well as for enzymology.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200453758