Cytotoxic flavonoids and alpha-pyrones from Cryptocarya obovata

One alpha-pyrone, obolactone (1), two chalcones, kurzichalcolactone B (2) and obochalcolactone (3), and two flavanones, oboflavanones A (4) and B (5), have been isolated from the fruits and the trunk bark of Cryptocarya obovata. The structures of the new compounds were elucidated by spectroscopic in...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2004-05, Vol.67 (5), p.858-862
Hauptverfasser:	Dumontet, V, Hung, N.V, Adeline, M.T, Riche, C, Chiaroni, A, Sevenet, T, Gueritte, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Circular Dichroism Crystallography, X-Ray Drug Screening Assays, Antitumor Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology Flavonoids - chemistry Flavonoids - isolation & purification Flavonoids - pharmacology General pharmacology Humans KB Cells Lauraceae - chemistry Medical sciences Molecular Conformation Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Bark - chemistry Plants, Medicinal - chemistry Pyrones - chemistry Pyrones - isolation & purification Pyrones - pharmacology
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Zusammenfassung:	One alpha-pyrone, obolactone (1), two chalcones, kurzichalcolactone B (2) and obochalcolactone (3), and two flavanones, oboflavanones A (4) and B (5), have been isolated from the fruits and the trunk bark of Cryptocarya obovata. The structures of the new compounds were elucidated by spectroscopic interpretations. The absolute configuration of obolactone (1) was established by circular dichroism. Obolactone (1) and obochalcolactone (3) display significant activity in in vitro cytotoxic assays against the KB cell line. Biosynthetic pathways for oboflavanones and obochalcolactone are suggested.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np030510h