The MPEG Effect:  Improving Asymmetric Processes by Simple Additives

The MPEG Effect:  Improving Asymmetric Processes by Simple Additives

Small amounts of simple methoxy poly(ethylene glycol)s (MPEGs) have a beneficial effect on catalyzed asymmetric aryl and alkyl transfer reactions onto aldehydes. The enantiomeric excesses of the products are improved, and this “MPEG effect” allows a reduction of the catalyst loading by a factor of 1...

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Veröffentlicht in:Journal of organic chemistry 2004-05, Vol.69 (11), p.3997-4000
Hauptverfasser: Rudolph, Jens, Hermanns, Nina, Bolm, Carsten
Format: Artikel
Sprache:eng
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Zusammenfassung:Small amounts of simple methoxy poly(ethylene glycol)s (MPEGs) have a beneficial effect on catalyzed asymmetric aryl and alkyl transfer reactions onto aldehydes. The enantiomeric excesses of the products are improved, and this “MPEG effect” allows a reduction of the catalyst loading by a factor of 10.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo0495079