Disassociated increases of adrenomedullin in the rat cerebrospinal fluid and plasma after salt loading and systemic administration of lipopolysaccharide
To determine the role of adrenomedullin (AM) in the fluid electrolyte homeostasis and endotoxin shock, cerebral spinal fluid (CSF) and plasma were sampled from rats after respective challenges. The AM levels were measured by a highly sensitive immunoassay. The AM levels in the CSF of the rats anesth...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2004-04, Vol.25 (4), p.609-614 |
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| creator | Chen, Lei Hashida, Seiichi Kitamura, Kazuo Eto, Tanenao Kangawa, Kenji Serino, Ryota Kis, Bela Yamashita, Hiroshi Ueta, Yoichi |
| description | To determine the role of adrenomedullin (AM) in the fluid electrolyte homeostasis and endotoxin shock, cerebral spinal fluid (CSF) and plasma were sampled from rats after respective challenges. The AM levels were measured by a highly sensitive immunoassay. The AM levels in the CSF of the rats anesthetized with ether (10.7±0.60
fmol/ml) were significantly higher than those with isoflurane (5.17±0.70
fmol/ml,
P |
| doi_str_mv | 10.1016/j.peptides.2004.02.001 |
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fmol/ml) were significantly higher than those with isoflurane (5.17±0.70
fmol/ml,
P<0.01), while the plasma level did not differ significantly. The CSF levels of the rats received 2% saline drinking increased to 3 and 4 folds at day 5 and day 7, respectively, while the plasma levels did not differ from controls at both time points. The AM levels in CSF or plasma increased to 1.5 and 3 folds at 1.5
h after intraperitoneal (i.p.) administration of lipopolysaccharide (LPS, 5
mg/kg), reached 6.5 and 30 folds at 6
h, respectively, while no change was observed in the controls. The present findings suggest that AM in the CSF is regulated independently from that in the plasma, the centrally synthesized AM plays and important role in the regulation of the fluid electrolyte homeostasis. Furthermore, the circulatory AM plays an important role in the endotoxin shock.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/j.peptides.2004.02.001</identifier><identifier>PMID: 15165716</identifier><identifier>CODEN: PPTDD5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adrenomedullin ; Animals ; Biological and medical sciences ; CSF ; Endotoxin shock ; Fundamental and applied biological sciences. Psychology ; Lipopolysaccharides - administration & dosage ; Male ; Peptides - blood ; Peptides - cerebrospinal fluid ; Plasma ; Rats ; Rats, Wistar ; Salt loading ; Shock, Septic - chemically induced ; Shock, Septic - metabolism ; Sodium Chloride, Dietary - administration & dosage ; Stress ; Vertebrates: endocrinology ; Water-Electrolyte Balance - drug effects</subject><ispartof>Peptides (New York, N.Y. : 1980), 2004-04, Vol.25 (4), p.609-614</ispartof><rights>2004 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-871c6826c753cb65289b309fe01edc04ddeb7ab2a441efdb800c9ca268a4eb473</citedby><cites>FETCH-LOGICAL-c491t-871c6826c753cb65289b309fe01edc04ddeb7ab2a441efdb800c9ca268a4eb473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0196978104000567$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15871337$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15165716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Lei</creatorcontrib><creatorcontrib>Hashida, Seiichi</creatorcontrib><creatorcontrib>Kitamura, Kazuo</creatorcontrib><creatorcontrib>Eto, Tanenao</creatorcontrib><creatorcontrib>Kangawa, Kenji</creatorcontrib><creatorcontrib>Serino, Ryota</creatorcontrib><creatorcontrib>Kis, Bela</creatorcontrib><creatorcontrib>Yamashita, Hiroshi</creatorcontrib><creatorcontrib>Ueta, Yoichi</creatorcontrib><title>Disassociated increases of adrenomedullin in the rat cerebrospinal fluid and plasma after salt loading and systemic administration of lipopolysaccharide</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>To determine the role of adrenomedullin (AM) in the fluid electrolyte homeostasis and endotoxin shock, cerebral spinal fluid (CSF) and plasma were sampled from rats after respective challenges. The AM levels were measured by a highly sensitive immunoassay. The AM levels in the CSF of the rats anesthetized with ether (10.7±0.60
fmol/ml) were significantly higher than those with isoflurane (5.17±0.70
fmol/ml,
P<0.01), while the plasma level did not differ significantly. The CSF levels of the rats received 2% saline drinking increased to 3 and 4 folds at day 5 and day 7, respectively, while the plasma levels did not differ from controls at both time points. The AM levels in CSF or plasma increased to 1.5 and 3 folds at 1.5
h after intraperitoneal (i.p.) administration of lipopolysaccharide (LPS, 5
mg/kg), reached 6.5 and 30 folds at 6
h, respectively, while no change was observed in the controls. The present findings suggest that AM in the CSF is regulated independently from that in the plasma, the centrally synthesized AM plays and important role in the regulation of the fluid electrolyte homeostasis. Furthermore, the circulatory AM plays an important role in the endotoxin shock.</description><subject>Adrenomedullin</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>CSF</subject><subject>Endotoxin shock</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Lipopolysaccharides - administration & dosage</subject><subject>Male</subject><subject>Peptides - blood</subject><subject>Peptides - cerebrospinal fluid</subject><subject>Plasma</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Salt loading</subject><subject>Shock, Septic - chemically induced</subject><subject>Shock, Septic - metabolism</subject><subject>Sodium Chloride, Dietary - administration & dosage</subject><subject>Stress</subject><subject>Vertebrates: endocrinology</subject><subject>Water-Electrolyte Balance - drug effects</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-O1DAMxisEYoeFV1jlAreWpO00zQ20_JVW4gLnyE1cNqM0KXGKNG_C45JhBsFtTz7458_291XVjeCN4GJ4fWhWXLOzSE3Led_wtuFcPKp2YpRdvReDelztuFBDreQorqpnRAdewF6NT6srUYC9FMOu-vXOERBF4yCjZS6YhEBILM4MbMIQF7Sb9y6UHsv3yBJkZjDhlCKtLoBns9-cZRAsWz3QAgzmjIkR-Mx8BOvC9z9dOlLGxZkivLjgKBcpF8NplXdrXKM_EhhzD6n89bx6MoMnfHGp19W3D--_3n6q7758_Hz79q42vRK5HqUww9gORu47Mw37dlRTx9WMXKA1vLcWJwlTC30vcLbTyLlRBtphhB6nXnbX1auz7prijw0p68WRQe8hYNxIy-Lhvlf8QVAo2Y5yVAUczqApDlHCWa_JLZCOWnB9Ck8f9N_w9Ck8zVtdwiuDN5cN21Rc_zd2SasALy8AkAE_JwjG0X9ccaPrTj-9OXNYjPvpMGkyDoNB6xKarG10D93yGxz2wE8</recordid><startdate>20040401</startdate><enddate>20040401</enddate><creator>Chen, Lei</creator><creator>Hashida, Seiichi</creator><creator>Kitamura, Kazuo</creator><creator>Eto, Tanenao</creator><creator>Kangawa, Kenji</creator><creator>Serino, Ryota</creator><creator>Kis, Bela</creator><creator>Yamashita, Hiroshi</creator><creator>Ueta, Yoichi</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20040401</creationdate><title>Disassociated increases of adrenomedullin in the rat cerebrospinal fluid and plasma after salt loading and systemic administration of lipopolysaccharide</title><author>Chen, Lei ; Hashida, Seiichi ; Kitamura, Kazuo ; Eto, Tanenao ; Kangawa, Kenji ; Serino, Ryota ; Kis, Bela ; Yamashita, Hiroshi ; Ueta, Yoichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-871c6826c753cb65289b309fe01edc04ddeb7ab2a441efdb800c9ca268a4eb473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adrenomedullin</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>CSF</topic><topic>Endotoxin shock</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Lipopolysaccharides - administration & dosage</topic><topic>Male</topic><topic>Peptides - blood</topic><topic>Peptides - cerebrospinal fluid</topic><topic>Plasma</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Salt loading</topic><topic>Shock, Septic - chemically induced</topic><topic>Shock, Septic - metabolism</topic><topic>Sodium Chloride, Dietary - administration & dosage</topic><topic>Stress</topic><topic>Vertebrates: endocrinology</topic><topic>Water-Electrolyte Balance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Lei</creatorcontrib><creatorcontrib>Hashida, Seiichi</creatorcontrib><creatorcontrib>Kitamura, Kazuo</creatorcontrib><creatorcontrib>Eto, Tanenao</creatorcontrib><creatorcontrib>Kangawa, Kenji</creatorcontrib><creatorcontrib>Serino, Ryota</creatorcontrib><creatorcontrib>Kis, Bela</creatorcontrib><creatorcontrib>Yamashita, Hiroshi</creatorcontrib><creatorcontrib>Ueta, Yoichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Lei</au><au>Hashida, Seiichi</au><au>Kitamura, Kazuo</au><au>Eto, Tanenao</au><au>Kangawa, Kenji</au><au>Serino, Ryota</au><au>Kis, Bela</au><au>Yamashita, Hiroshi</au><au>Ueta, Yoichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disassociated increases of adrenomedullin in the rat cerebrospinal fluid and plasma after salt loading and systemic administration of lipopolysaccharide</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>2004-04-01</date><risdate>2004</risdate><volume>25</volume><issue>4</issue><spage>609</spage><epage>614</epage><pages>609-614</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>To determine the role of adrenomedullin (AM) in the fluid electrolyte homeostasis and endotoxin shock, cerebral spinal fluid (CSF) and plasma were sampled from rats after respective challenges. The AM levels were measured by a highly sensitive immunoassay. The AM levels in the CSF of the rats anesthetized with ether (10.7±0.60
fmol/ml) were significantly higher than those with isoflurane (5.17±0.70
fmol/ml,
P<0.01), while the plasma level did not differ significantly. The CSF levels of the rats received 2% saline drinking increased to 3 and 4 folds at day 5 and day 7, respectively, while the plasma levels did not differ from controls at both time points. The AM levels in CSF or plasma increased to 1.5 and 3 folds at 1.5
h after intraperitoneal (i.p.) administration of lipopolysaccharide (LPS, 5
mg/kg), reached 6.5 and 30 folds at 6
h, respectively, while no change was observed in the controls. The present findings suggest that AM in the CSF is regulated independently from that in the plasma, the centrally synthesized AM plays and important role in the regulation of the fluid electrolyte homeostasis. Furthermore, the circulatory AM plays an important role in the endotoxin shock.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15165716</pmid><doi>10.1016/j.peptides.2004.02.001</doi><tpages>6</tpages></addata></record> |
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| ispartof | Peptides (New York, N.Y. : 1980), 2004-04, Vol.25 (4), p.609-614 |
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| subjects | Adrenomedullin Animals Biological and medical sciences CSF Endotoxin shock Fundamental and applied biological sciences. Psychology Lipopolysaccharides - administration & dosage Male Peptides - blood Peptides - cerebrospinal fluid Plasma Rats Rats, Wistar Salt loading Shock, Septic - chemically induced Shock, Septic - metabolism Sodium Chloride, Dietary - administration & dosage Stress Vertebrates: endocrinology Water-Electrolyte Balance - drug effects |
| title | Disassociated increases of adrenomedullin in the rat cerebrospinal fluid and plasma after salt loading and systemic administration of lipopolysaccharide |
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