Disassociated increases of adrenomedullin in the rat cerebrospinal fluid and plasma after salt loading and systemic administration of lipopolysaccharide

To determine the role of adrenomedullin (AM) in the fluid electrolyte homeostasis and endotoxin shock, cerebral spinal fluid (CSF) and plasma were sampled from rats after respective challenges. The AM levels were measured by a highly sensitive immunoassay. The AM levels in the CSF of the rats anesth...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2004-04, Vol.25 (4), p.609-614
Hauptverfasser:	Chen, Lei, Hashida, Seiichi, Kitamura, Kazuo, Eto, Tanenao, Kangawa, Kenji, Serino, Ryota, Kis, Bela, Yamashita, Hiroshi, Ueta, Yoichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenomedullin Animals Biological and medical sciences CSF Endotoxin shock Fundamental and applied biological sciences. Psychology Lipopolysaccharides - administration & dosage Male Peptides - blood Peptides - cerebrospinal fluid Plasma Rats Rats, Wistar Salt loading Shock, Septic - chemically induced Shock, Septic - metabolism Sodium Chloride, Dietary - administration & dosage Stress Vertebrates: endocrinology Water-Electrolyte Balance - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	To determine the role of adrenomedullin (AM) in the fluid electrolyte homeostasis and endotoxin shock, cerebral spinal fluid (CSF) and plasma were sampled from rats after respective challenges. The AM levels were measured by a highly sensitive immunoassay. The AM levels in the CSF of the rats anesthetized with ether (10.7±0.60 fmol/ml) were significantly higher than those with isoflurane (5.17±0.70 fmol/ml, P
ISSN:	0196-9781 1873-5169
DOI:	10.1016/j.peptides.2004.02.001